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Additional weight-related outcomes included the percentage of patients achieving 5%, 10%, 15%, and 20% weight reduction targets, absolute weight change from index (kg), absolute change in BMI (kg/m), and BMI class shift, defined as a transition from one BMI category to a lower one over the 6-month follow-up

Users may also experience a slight increase in libido and mild appetite suppression

Therapeutic interventions must account for this crosstalk, since targeting a single pathway often proves inadequate due to compensatory adaptive mechanisms

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