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In addition to direct neuronal activation, MC-derived mediators further contribute to neuronal sensitization by increasing the activity of membrane-bound TRP channels, particularly TRPA1 and TRPV1, which lower the activation threshold of neurons and establish a state of peripheral hyperexcitability (40, 91, 103)

Flare-ups vary between individuals but usually occur a few times per month

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Between 2019 and 2022, unit sales of Zyn grew more than sixfold, and Philip Morris International went on to acquire Zyns parent company for roughly $16 billion

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