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Unlike cigarette or cigar tobacco, pipe tobacco is generally cut a bit coarser and blended with a greater variety of flavourings, creating a rich and complex smoking experience that sets it apart from regular cigarettes
While the Vuse application ran 150,000 pages long, the IQOS PMTA was said to run some 2 million pages long and cost millions of dollars to produce
Barnes PJ (2020) Oxidative stress-based therapeutics in COPD
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In addition, some of the flavoring chemicals have been reported to be harmful to cells in the lung including cinnamaldehyde (cinnamon flavor), diacetyl and 2,3-pentanedione or acetoin (butter flavor), maltol (malt flavor), pulegone (menthol and mint flavor) (Zaccone et al., 2015
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