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The peak of withdrawal in 48 to 72 hours The most difficult period of withdrawal occurs within 48 to 72 hours after the last nicotine intake

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A study published in JAMA Internal Medicine in 2014 concluded: "E-cigarette use by smokers was not followed by greater quitting, or reduction in consumption one year later." Another 2015 study in the journal Addiction found that daily use of e-cigarettes seemed to be associated with an increase in the rate of attempts to quit smoking and less smoking, though not increased rates of quitting