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Because a combination of a nicotine replacement therapy and an antidepressant is dramatically more effective than a single therapy alone, the government's report on treating tobacco dependence urges that "all patients attempting to quit should be encouraged to use effective pharmacotherapies for cessation except in the presence of special circumstances." First-line therapies for smoking cessation are (a) nicotine replacement therapy, which is available in many forms (gum, patches, lozenges, nasal spray, and an oral inhaler), and (b) a psychotropic drug (bupropion/Zyban)

The urinary measurement of nicotine metabolites has several applications, including public tobacco exposure monitoring, nicotine replacement therapy evaluation, drug therapy assessment, forensic toxicology analysis, and life or health insurance application

Quitlines like WaytoQuit.org's 1-800-QUIT-NOW can be one of the best resources out there for individuals looking to kick the habit

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