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Abbreviations AEs: Adverse events ANOVA: Analysis of variance BAI: Beck Anxiety Inventory BDI-II: Beck Depression Inventory-II BMI: Body mass index CAR: Continuous abstinence from vaping CAR: Continuous abstinence rate CI: Confidence interval CoEHAR: Center of Excellence for the Acceleration of HArm Reduction CONSORT: Consolidated Standards of Reporting Trials CPCT: Centre for the Prevention and Treatment of Tobacco Addiction EC: Electronic cigarette eCO: Exhaled carbon monoxide EudraCT: European Union Drug Regulating Authorities Clinical Trials Database FDA: Food and Drug Administration INNCO: International Network of Nicotine Consumers Organizations LIAF: Italian Anti-Smoking League mcEq: Modified cigarette evaluation questionnaire Mnui: Modified Nicotine Use Inventory MNWS: Minnesota Nicotine Withdrawal Scale OR: Odds ratio P: Observed level of significance PSECDI: Penn State Electronic Cigarette Dependence Index RCT: Randomized controlled trial TQD: Target quit date UOC MCAU: Complex operating unit of Medicine and Surgery of Acceptance and Urgency V1: Baseline visit VAS: Visual analog scale References European Commission

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Research Notes Journal of Alternative and Complementary Medicine Olfactory stimulation with black pepper reduces nicotine craving in abstinent smokers. Proceedings of the National Academy of Sciences -Caryophyllene is a selective CB2 agonist with anxiolytic potential. Phytomedicine - Limonene has anti-anxiety activity via adenosine A2A receptor-mediated regulation of dopaminergic and GABAergic neuronal function in the striatum

Yet another study found that mice injected with asbestos developed cancer, but with a latency period that seemed inexplicably long, given the materials potency as a human carcinogen