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To be specific, the expression levels of hsa-miR-3913-5p, hsa-miR-574-5p, hsa-miR-500a-5p and piR-50603 in SAE-derived EVs exposed to CSE were significantly upregulated, whereas the expression levels of hsa-miR-618 and pi-R52900 were significantly downregulated [82]

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[43] The evidence suggests that exposure to nicotine between the ages of 10 and 25 years causes lasting harm to the brain and cognitive ability

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