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The C-terminal domain contributes, together with the N-terminal domain, to shaping the co-substrate binding site, which is termed H-site, from the hydrophobic nature of co-substrates

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Theoretically, the two compounds target completely different receptor systems (amylin receptors for cagrilintide, GLP-1/GIP/glucagon for retatrutide), which suggests they could work synergistically without receptor overlap

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