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4.2 Imaging 4.2.1 Introduction to imaging techniques for ferroptosis detection Studies combining imaging techniques such as MRI and magnetic nanoparticles for in vivo ferroptosis observation initially emerged in oncology research, where ferroptosis modulation represents a novel treatment approach that potentially overcomes resistance to conventional cancer therapies

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With an active site at the external surface of the plasma membrane, GGT catalyzes the transfer of -glutamatyl moiety from GSH to free amino acid, and thereby, released cysteine-glycine dipeptide that can be transported in its intact form via the proton-coupled oligopeptide transporter family member PEPT2 (35, 36) or further cleaved by dipeptidases to cysteine and glycine

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