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While one study has reported reductions in oxidative stress and microglial activation, a recent highquality investigation in 5XFAD and APP/PS1 mice found no improvement in neuropathology, neuroinflammation, behaviour, or cognitive outcomes following treatment with semaglutide or tirzepatide

Looking Ahead As this review shows, there are several existing pooled procurement platforms with significant longevity, broad geographic reach, offering a range of commodities, allowing access to countries that have transitioned off donor support, and in which the U.S

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Metabolic protection: They improve insulin sensitivity and protect against age-related metabolic disorders in animal models

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