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The plasma glucose level of male obese Zucker rats also decreased significantly after long-term oral administration of nicotine with drinking water, and the glycogen content, glycogen synthase activity and gluconeogenesis in the liver were significantly lower than those in the control group, indicating that nicotine can reduce insulin resistance in obese diabetic rats by reducing the release of glucose in the liver, thus reducing the level of blood sugar to some extent (Liu et al., 2003)