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Despite progress, smoking and exposure to secondhand smoke are responsible for more than 480,000 premature deaths annually and more than $300 billion in health care expenses and other economic costs each year

One animal study demonstrated that PNE increases expression levels of cholesterol side-chain cleavage enzyme (P450scc) and adrenal steroid acute regulatory protein (StAR) in pregnant rats and reduces the levels of 11-hydroxysteroid dehydrogenase-2 (11-HSD-2) which is responsible for the inactivation of mother-derived GC [46]

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