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On the basis of these findings, dual-receptor agonists for GLP-1/GIP, GLP-1/glucagon as well as triple-receptor agonists were propagated and successively developed for the treatment of T2D and obesity (3941, 51)

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Liraglutide, a long-acting GLP-1 agonist, is also approved as adjunct pharmacotherapy with lifestyle modification for weight management, particularly for patients with BMI 27 kg/m2, with or without T2DM