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GLP-1 receptor agonists (e.g., Ozempic, Wegovy) work by mimicking a hormone called glucagon-like peptide-1, which regulates blood sugar, appetite, and metabolism

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the heteroatom linker can be nitrogen, the heterocycles can be pyrrolidines, piperidines, oxazolidines, isoxazolidines, thiazolidines, isothiazolidines, pyrrolidinones, piperidinones, oxazolidinones, isoxazolidinones, thiazolidinones, isothiazolidinones, and succinimides

This underscores the need for close monitoring when combining QUE-containing supplements with drugs metabolized by P-gp or CYP3A4 (e.g., cyclosporine)

PMCID: PMC9729155