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Acknowledgements We would like to thank all our participants who took the time to participate in this study, as well as the OASIS clinical team members and the radiographers at the Centre for Neuroimaging Sciences

Angela Me, the head of the UNODC's Statistics and Surveys Section which prepared the report, says one of the main reasons for the jumps appears to be the increased availability of opium and heroin on the Afghan market and accompanying drops in prices

These three patients tended to be younger than those who never experienced worsening of motor symptoms due to smoking (57.0 vs