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After analyzing the physical characteristics and chemicals in the smoke and tobacco filler in 13 varieties of American Spirit cigarettes, researchers found that American Spirit cigarettes generally have more tobacco filler, and, as a result, produce a higher number of puffs which may expose the brands smokers to more tobacco chemicals per cigarette than smokers of other brands

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They produce reactive species including trace ozone, provide no mechanical filtration, and have no published CADR data because they do not move air

Uk } : CS1 maint: multiple names: authors list (link) "6-Methylnicotine: a new nicotine alternative identified in e-cigarette liquids sold in Australia"