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In contrast, organs with high sensitivity to glucocorticoids, such as the liver, adipose tissue, and skeletal muscle, highly express 11-HSD1, which catalyzes the reverse reaction of 11-HSD2, thereby increasing cortisol bioavailability (1)

15,276 The activation of GLP-1R is linked to decreased NF-B pathway activity Treatment with GLP-1RAs can effectively mitigate chondrocyte apoptosis caused by endoplasmic reticulum stress and alleviate the associated inflammatory response

Glucose variability and beta-cell response by GLP-1 analogue added-on CSII for patients with poorly controlled type 2 diabetes

doi: 10.1186/1472-6882-8-4

In animal studies, tirzepatide has been shown to cause thyroid C-cell tumors