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90 A vaginal gel made with hops extract combined with hyaluronic acid (a connective tissue component) and vitamin E, applied in the amount of 2.5 grams nightly for one week followed by twice weekly for 11 weeks, relieved vaginal dryness and improved all vaginal symptoms in an uncontrolled trial in 100 postmenopausal women

Nature 528 , 262266 (2015)

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10.1021/jm200036n 9 AnderssonH.DemaegdtH.VauquelinG.LindebergG.KarlnA.HallbergM

Additionally, the precise dosing of nasal sprays helps maintain control over administration, reducing the risk of side effects and improving study results