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Funding information We did not receive any funding to conduct this analysis

2014 (10) CD002109

But two or three boxes

Conversely, continued declines in cigarette-only use align with decades of tobacco control efforts and evolving norms surrounding smoking

The reduced digestive impact of NRTs likely results from: Lower peak nicotine levels compared to cigarettes or snus More gradual nicotine absorption rates Absence of additional tobacco compounds that may affect digestion Steady release formulations (especially patches) that prevent nicotine spikes For people quitting smoking who are concerned about constipation, transitioning through nicotine pouches or gum before eliminating nicotine completely might help manage digestive changes more comfortably