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The CAGE questionnaire for smoking (modified from the familiar CAGE questionnaire for alcoholism), the four Cs test and the Fagerstrm Test for Nicotine Dependence help make the diagnosis of nicotine dependence based on standard criteria

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Because cannabinoids like cannabidiol (CBD) and tetrahydrocannabinol (THC) may inhibit the liver enzyme cytochrome P2C19 (CYP2C19), marijuana may decrease the metabolism of CYP2C19 substrates, such as escitalopram and sertraline

It is normal to try several times before finally quitting long-term