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Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1

however, the oestrous cycle was disrupted, and the serum AMH levels and uterine and ovarian organ coefficients were all reduced in a dose-dependent manner

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Immune cells-particularly CD8+ T cells-are highly dependent on mitochondrial ATP supply, and this bioenergetic failure limits their proliferation, cytokine production, and cytotoxic activity, contributing to T cell exhaustion (86, 87)