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The knowledge of the delivered dose and its time course using reliable dosimetry techniques is critical to interpreting and potentially extrapolating results from in vitro assays, but also to gain in homogeneity and be able to compare different toxicological studies [18]

Dependency refers to the physical need for a substance due to the build-up of tolerance , while addiction is characterized by detrimental consequences and compulsive behaviours despite knowing these negative outcomes

US Department of Health, Education, and Welfare

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