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Cell studies show inflammation and some cell death, but the toxic effect of vapour on cells appears to be more related to chemicals other than either PG or VG

inhibiting the synthesis of mucus, the substance that helps protect the intestinal tract from inflammation and infections changing mucus composition causing an imbalance in the gut bacterial community between beneficial and harmful strains increasing cell death in the tissue lining the intestine increasing inflammation Smoking and liver disease The development of liver cancer may accelerate in people with chronic hepatitis infections

Nicotine affects dopamine, so mood changes are common early on

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American Spirit American Spirit is a premium cigarette brand owned by Reynolds American