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Yet another compound, Honokiol (HKL), has been shown to protect against doxorubicin-induced cardiotoxicity by activating SIRT3, which helps reduce ROS production, prevent mitochondrial fragmentation, and promote mitochondrial fusion 187

To assess the nanotoxicity in a complex way, all-inclusive hemocompatibility testing, which includes assessment of hematocrit, hemostasis, nano-cell interactions, immunotoxic effects, etc., is recommended [448]

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