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The researchers also found that changes in gene expression following growth in the medium generated using e-cigarette vapour were very similar to those changes seen when the cells were grown for the same period of time in the medium generated using tobacco smoke

Animal studies show that the response to nicotine depends on the dose, rising as the dose increases and then falling off again so the curve of dose-dependence is an upside-down U-shape

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Peterson subsequently revealed that she had been Bogarts mistress for 13 years