77 Differential methylation patterns of cg05575921, the most frequently replicated probe, located in the intronic region of AHRR , have also been associated with multiple smoking traits: CPD, serum cotinine, cumulative amount smoked (pack-years), and time since quitting
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Several studies had reported the prevalence of smoking among adult women to be very low 1,29 (making prevalence of smoking among mothers an unsuitable measure for inclusion in the current study), contrasting with the high prevalence of fathers smoking
In terms of nicotine delivery from IQOS, a randomized crossover study showed that the nicotine delivery rate was similar between IQOS and CS with lower plasma nicotine peak after IQOS use (70% of CS peak) 87 , and another study reported a similar pharmacokinetic profile of nicotine from IQOS and CS with similar user satisfaction 88
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