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Patients may be very short of breath with COPD, need oxygen, be on a ventilator, or have lung cancer

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Ongoing studies in our group, utilizing non-invasive imaging of the tumor reductive state, circulating biomarkers of Nrf2 hyperactivation and spatial transcriptomic analysis of primary and recurrent HNSCC tumors are attempting to define the clinical window in which activation of this pathway is expected to generate a maximal deleterious effect on both conventional and ICI-based treatment efficacy

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