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Individuals with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 should not use GLP-1 agonists

J Biol Chem 288:74677480 Sikiric P (1999) The pharmacological properties of the novel peptide BPC 157 (PL-10)

Dec 2010;30(6):281-4

Similarly, in the United Kingdom Prospective Diabetes Study (UKPDS), only 34% of patients attained an A1c age 65) and patients with hepatic or renal disease are more likely to experience frequent and severe hypoglycemic reactions, particularly if the goals of therapy aim for inappropriately tight glycemic control (20)

Patrick, R.P., et al