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Neuromuscular function was determined via balance beam in females [Young ( n = 8), Old Con ( n = 12), and Old mAb ( n = 15)] and males [Young ( n = 8), Old Con ( n = 9), and Old mAb ( n = 9)]
Phase 3 data will determine whether this difference persists in larger, more diverse populations with longer follow-up
Diabetes Obes Metab 14:514 Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK, The PROactive Investigators (2005) Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive study (PROspective pioglitAzone clinical trial in macro vascular events): a randomised controlled trial
Overall, the data demonstrate that ACLY and ACSS2 are not the sole sources of acetyl-CoA in the nuclear-cytosolic compartment, and that the carnitine shuttle participates in the transit of acetyl-CoA from mitochondria to cytosol to support lipogenesis and histone acetylation
Retatrutide is the lead candidate in this category, but is still in clinical trials
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