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doi: 10.1016/j.ynpai.2022.100091 44

Brain 139 , 14171432 (2016)

These compounds block the action of an enzyme, dipeptidyl peptidase-IV, which normally rapidly degrades GLP-1

Contribution of interleukin1 to the inflammationinduced increase in nerve growth factor levels and inflammatory hyperalgesia

Initially, these phagocytes adopt a pro-inflammatory, microbicidal program characterized by elevated production of reactive oxygen species (ROS), nitric oxide (NO), proteolytic enzymes, and pro-inflammatory cytokines like IL-1, IL-6, and TNF-, enabling efficient pathogen clearance [39]