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Moreover, the previous pilot RCT focused on smokers enrolled in smoking cessation services, which limited the interventions generalizability

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Spontaneous rupture of large arteries was not observed at all and, in particular, neither in the 6 patients with the COL1A1 p.(Arg312Cys) missense variant nor in 2 individuals with different COL5A1 glycine substitutions at the C-terminal domain (Additional Table 1), which represent variants previously associated with a possible higher risk of vascular events [16]

For example, larger pack sizes might come at a discounted rate per cigarette, encouraging bulk purchasing