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Additional studies in cynomolgus monkeys have confirmed the potent dose-dependent, weight-lowering effects of chronic GLP-1R/GcgR co-agonism [78], supporting the translational promise of this novel balanced agonism for obesity and type 2 diabetes
Scirica BM, Braunwald E, Raz I, Cavender MA, Morrow DA, Jarolim P, Udell JA, Mosenzon O, Im K, Umez-Eronini AA, Pollack PS, Hirshberg B, Frederich R, Lewis BS, McGuire DK, Davidson J, Steg PG, Bhatt DL
The data shows that semaglutide at the full weight loss dose has somewhat higher rates of nausea and vomiting compared to tirzepatide, though the comparison between semaglutide and tirzepatide side effects involves many variables beyond simple percentage comparisons
Research integrity requires controlled variables