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Although RCTs are required to determine the effectiveness or safety of nicotine products as smoking cessation tools, outcomes related to latency, such as oral cancer, require long-term observational studies

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(3) The proprietor or other person in charge of an enclosed indoor workplace where a smoking cessation program, medical research, or scientific research is conducted or performed must conspicuously post, or cause to be posted, signs stating that smoking is permitted for such purposes in designated areas in the enclosed indoor workplace

Slaveholding was concentrated in the hands of a small elite of planters and merchants, but racial distinctions were weakly defined and intermarriage became frequent