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Zero-dimensional (0D) GO quantum dots (GOQDs) represent an emerging class of oxygen-rich materials with dimensions less than 20 nm 132

copper activates hypoxia-inducible factor (HIF)-1, and when copper is chelated, HIF-1-mediated VEGF expression is blocked (164,165)

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Thanks to the enzyme Glutathione reductase, the oxidized Glutathione returns to its original form, regaining the hydrogen molecule and continuously self-regenerating to perform its functions