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Similarly, increased hyperphosphorylation of NS5A correlates with lower replication levels 42,63,64 and decreased interaction between NS5A and a cellular factor, human vesicle-associated membrane-protein associated protein A (hVAP-A) 63

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Figure 3: Data from Table 5, taken from Bays et al., 2026 Taken together, the Phase 2 efficacy, safety and tolerability and the prediabetes-to-normoglycaemia signal make VK2735 a competitive injectable against the first generation GLP-1 medications

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