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Endothelial dysfunction is characterized by reduced nitric oxide (NO) synthesis and/or bioavailability within peri-endothelial environment, where NO is responsible for maintenance of vascular tissue integrity 3

In chronic UV exposure models SKH-1 hairless mouse 311 nm UVB 3 per week for 12 weeks (establishing cumulative photoageing) GHK-Cu (topical or s.c.) produces significantly greater PRIMOS surface roughness Ra/Rz reduction, Masson trichrome collagen red:yellow ratio improvement (mature vs immature collagen), and SA--gal+ dermal fibroblast density reduction compared to Epitalon at equivalent dosing schedules

Skipping it introduces bacteria directly into a subcutaneous wound

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Chang HC, Huang YC, Lien YJ, Chang YS