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doi:10.1161/HYPERTENSIONAHA.107.097154 26

1c, using HAPC analysis, the effects of generation (i.e., cohort effect) look more variable than age and period effects

Only prospective cohort and casecontrol studies were included for estimating doseresponse risk curves, but cross-sectional studies were also included for estimating the age pattern of smoking risk on cardiovascular and circulatory disease (CVD) outcomes