One of the distinctive features of IGF-1 LR3 is its reduced affinity for insulin-like growth factor binding proteins (IGFBPs), a family of proteins that regulate the distribution and accessibility of IGFs within circulation
Antagonists or neutralizing antibodies against IL-1, TNF-, and IL-6, such as IL-1Ra and anti-TNF-, have been extensively studied in OA
10.1007/s11033-022-08115-4 200 MonteiroJ
Therefore, defining astrocyte subpopulations necessitates a multidimensional framework that considers spatial distribution, morphological features, transcriptional programs, specialized cellular functions and their contributions to disease-associated processes
Epub ahead of print, doi:10.1056/NEJMoa907569