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This review synthesizes current insights into the mechanisms underlying residual symptoms in HT and critically evaluates contemporary and emerging therapeutic approaches aimed at improving patient-reported outcomes and long-term disease management 1 Introduction Hypothyroidism is a common endocrine disorder characterized by insufficient thyroid hormone production, estimated to affect a range of 4.825.8% of women and 0.97.9% of men in the general population, with a variable prevalence due to different definitions used and the population studied (13)