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Worldwide, tobacco use is the sixth leading cause of lost disability-adjusted life-years, a measurement that combines the effects of morbidity and mortality for comparative purposes between and across health outcomes (Murray and Lopez, 1997)

We realize that there are other factors like ocular perfusion pressure that might play a role when assessing changes in retinal vessel density

With increasing size, the price pushes towards an upper limit

The eligibility criteria for this review were as follows: 1) the study design was an RCT or an observational study