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In CHR-P individuals, hippocampal hyperactivity has been observed in vivo [38,39,40,41,42], which as a result of neurovascular coupling is associated with increased regional cerebral blood flow or volume (rCBF or rCBV) by arterial spin labeling (ASL) or gadolinium-contrast magnetic resonance imaging (MRI), respectively

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Benzodiazepine receptors mediate regional blood flow changes in the living human brain

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Edelman said both studies were extremely well done and their findings convincing because of their enormous size