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Depression and anxiety Over 20 million adults in the United States suffer from depression (30), and multiple studies have demonstrated comorbidity between depression and electronic cigarette use (16, 3139)

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Interestingly, they found that animals exposed to nicotine prenatally and given nicotine during adolescence had worse outcomes and greater neurotoxicity as compared to controls, indicating the neurotoxicant actions may contribute towards the association between PNE and subsequent smoking in offspring