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STUDY DESIGNS SUSTAIN 4: Head-to-head vs Lantus (insulin glargine U-100) 1,9 Study design: 30-week, randomized, open-label, active-controlled, parallel-group, multinational, multicenter trial to evaluate the efficacy and safety of Ozempic injection vs insulin glargine U-100

According to the 2024 multi-society guidance from the ASA and other professional organizations, most patients can continue GLP-1 receptor agonists before elective procedures with appropriate risk assessment and mitigation strategies

Donahue SP, Phillips LS

Some researchers also investigate combination approaches, pairing GLP-1 agonists with other peptides that target complementary pathways

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