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"The world litters 4.5 trillion cigarette butts a year

Effects of nicotine patch vs varenicline vs combination nicotine replacement therapy on smoking cessation at 26 weeks: a randomized clinical trial

8 hours Nicotine is addictive largely because its absorbed into the bloodstream quickly, leading to the release of adrenaline and dopamine (and giving you that familiar headrush), and wears off quickly causing you to seek the hit again and again

Key strengths include the exceptionally large sample size, long follow-up, and detailed adjustment for clinical, behavioral, and socioeconomic confounders, allowing robust assessment of interactions between initiation age and smoking intensity

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