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Furthermore, since metabolism of varenicline represents less than 10% of its clearance, drugs known to affect the cytochrome P450 system are unlikely to alter the pharmacokinetics of CHANTIX [see Clinical Pharmacology (12.3)]

Indian Journal of Public Health, 55(3):169-176

Doctors say there are several reasons marijuana might cause more lung damage than tobacco

WRAL.com

For years cigarettes have focused their marketing efforts as having lower levels of tar in their cigarettes, but the problem is that low tar still means that you are still inhaling the chemical into your lungs