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In the discontinuation of chronic nicotine treatment or late in life treatment initiation experiments, an initial cohort of 200 individuals of the corresponding genotypes was separated in two groups of 100 individuals each: one group was treated with nicotine only for the first half of its life-expectancy (first 60 days after eclosion), while the other was treated only for the second half of its life expectancy (treatment initiated only after 60 days of aging)

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