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In these mice, insufficient PDGFR/PI3K/AKT activation is primarily due to reduced PRKN expression ( 5.2 Mitochondrial dynamics in IPF Alveolar epithelial cells are important therapeutic cells in the pathogenesis of IPF, and researchers have observed enlarged mitochondria in such cells in IPF ( 5.3 Mitochondrial biogenesis in IPF Repeated damage to type II alveolar epithelial cells is an important cause of pulmonary fibrosis, but repeated damage to such cells is not necessary in the progression of pulmonary fibrosis ( 6 Conclusion As research into mitochondrial quality control has progressed, researchers have identified important roles in disease development, particularly in neurodegenerative diseases such as Parkinsons and cardiovascular disease, which have proved worth exploring ( Statements Author contributions XH and GL: funding acquisition, conceptualization and supervision