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The effect of nicotine is to lower progesterone levels by inhibiting the progesterone synthesis and by reduction of cell growth, to limit oestrogen biosynthesis, to decrease peripheral blood flow, and to impair fallopian tube and uterus contractility 21,22,23,67,68,69

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Moreover, untargeted analysis of VOCs and unknown organic molecules by LC-MS as well as GC-MS might be the right path to further understanding the toxicological risks of vaping. Clinical studies should include the effects of exposure to e-cigs by bystanders, as active regulations are considerably tolerant regarding the commercialization and use of e-cigarettes