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Widespread and ongoing shortages of the brand-name drugs from pharmacies especially for weight loss, as pharmacists prioritise stock for people with diabetes have left patients turning to compounding pharmacies, which are making their own version of the drugs en masse

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Side Effects * Dry cough * Dizziness * Hypotension * Hyperkalemia * Headache * Fatigue * Renal impairment * Angioedema (rare but potentially life-threatening) Contraindications * Pregnancy (especially the second and third trimesters) * History of ACE inhibitor-induced angioedema * Bilateral renal artery stenosis * Significant hyperkalemia * Concomitant use with certain medications in selected patients (e.g., some combinations affecting the reninangiotensin system) Monitoring * Blood pressure * Serum potassium * Serum creatinine and estimated glomerular filtration rate (eGFR) * Clinical signs of hypotension or angioedema Drug Interactions * Potassium supplements and potassium-sparing diuretics may increase the risk of hyperkalemia

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