Vimentin protects the nucleus giving it stability and perinuclear stiffness, which hinders 3D motility
Ranjan (CRC Press, Boca Raton, 2018), pp
Produced by osteoblasts and released into circulationparticularly in its undercarboxylated formosteocalcin has been shown in animal models to enhance insulin secretion, improve insulin sensitivity, increase energy expenditure, and stimulate testosterone production ( Mechanistically, osteocalcin signaling has been linked to the G proteincoupled receptor GPRC6A, providing a plausible pathway through which bone-derived signals influence pancreatic -cells, adipocytes, and Leydig cells
Considering the significant involvement of lipid metabolism in human reproduction, gaining a deeper insight into dyslipidemia and female reproduction could have important clinical implications for the diagnosis and management of female reproductive disorders
These effects are attributed to CypD-mediated mitochondrial depolarization
